Workshop on cryopreservation and recovery techniques in the laboratory mouse november 16 20, 2015 consiglio nazionale delle ricerche campus a. At the same time, you need to drag the mouse over the page in the direction you want. With inclusions of the newly revised european standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. The pyfpdf package is actually a port of the free pdf. Pathophysiology including noninfectious diseases skin and adnexes of the laboratory mouse cardiovascular system respiratory tract gastrointestinal system and metabolism inbred mouse models for autoimmune disease hematology of the mouse the social behaviour of mice and its sensory control neuroendocrine immune network in stress circadian rhythms of the mouse gerontology diversity of spontaneous neoplasms in commonly used inbred strains and stock of laboratory mice. The laboratory mouse handbook of experimental animals hedrich hans, hans hedrich among animals used in research, teaching and testing, mice are now widely recognized as the most important. Guide for the care and use of laboratory animals, 8th. To add a popup note to the markup, select the hand tool, and doubleclick the markup. It is produced by lack of opening of the vaginal membrane, and appears as swelling between the anus and genital papilla giving the appearance of a male mouse. Buzzatitraverso i00015 monterotondo scalo, rome, italy the consiglio nazionale delle ricerche, european mouse. It is located in a park in front of the institute of cytology and genetics of the russian academy of sciences. Coding of facial expressions of pain in the laboratory mouse. The mouse should have very limited movement of the head and front legs. However i have found that there is another one called pyfpdf or fpdf for python.
A selected area appears that you can expand and reduce, but you cant let go of the left mouse. Infection of skin scratches and bite wounds with mouse or humanborne opportunistic microbes demands attention through a strict occupational medical treatment program national research council, 1997. Biomed central page 1 of 10 page number not for citation purposes bmc genomics research article open access efficient single nucleotide polymorp hism discovery in laboratory rat strains using wild. Ergonomic guide to computer based workstations page 5 of 19 pn 134 version 1 last updated august 2012 specific seating features and when they might be required are outlined in the table below. Grab the skin on the mouse s back between your thumb and index finger. The laboratory mouse, second edition, deserves a place on the shelf of every laboratory animal medicine residency library and practitioner not only for its coverage of mouse biology and medicine, but also for its detailed descriptions of the emerging technologies and issues affecting the use of mice. There are hundreds of types of mice, divided into subfamilies of either old world or. Streptozotocin use in mice and rats version 1 date of publication.
Dogs 1994 recognition and alleviation of pain and distress in laboratory animals 1992 education and training in the care and use of laboratory. The laboratory mouse, second edition is a comprehensive book written by international experts. The laboratory mouse handbook of experimental animals hedrich hans, hans hedrich among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. Dilute meloxicam if needed to provide accurate volume of 0. Use annotation and drawing markup tools to add comments in. Based on serologic surveys, parvo viruses are some of the most common viral pathogens in wild and laboratory rat.
Rat and mouse anesthesia and analgesia formulary and general drug information approved. The case for genetic monitoring of mice and rats used in. Mouse genetics has experienced many milestones over the last few decades, from the generation of inbred lines which consistently exhibited a coat color trait or susceptibility to tumors in the early. An sop may have several distinct parts to help organize and outline. In north america, they are the deer mouse, the whitefooted mouse, the rice rat, and the cotton rat.
Internet and print resources to facilitate pathology. Mouse genetics student guide independence high school. One of the most timeconsuming activities in research laboratories is looking up information. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project. A mouse is a small rodent with a pointed nose, furry round body, large ears and a long, often hairless, tail.
Rodent surgical incisions closure guidelines and recommendations. Please make sure to upload the whole publication to your server. The laboratory mouse handbook of experimental animals. A defect that may occur in the maturing young female mouse. Put the mouse down on the metal grating in the front of the hood, so the mouse can grab on to the grating. The monument to the laboratory mouse is a sculpture in the city of novosibirsk in siberia, russia. Currently, there is the potential to generate over 200,000 mutant mouse strains between existing mouse strains over 24,000 and genetically modified mouse embryonic stem cells over 209,000 that have been entered into the international mouse strain resource center imsr from laboratories. The mouse allows you to move the cursor and click programs.
It could be on a hard drive on this computer, or on a network. Standard operating procedure for tamoxifen in animals. Time approximately 45 minutes question what is the effect of the genes of the parental mice on the fur color of the offspring mice. Each drug affects different neurotransmitters at the synapse in different ways. Page 2of2 nsaid analgesia for adult rodents sop meloxicam metacam limited long term safety information has been published. Only some kinds of mice and rats can give people hantaviruses that can cause hps. The laboratory mouse, second edition, deserves a place on the shelf of every laboratory animal medicine residency library and practitioner not only for its coverage of mouse biology and medicine, but also for its detailed descriptions of the emerging technologies and issues affecting the use of mice in researchmy copy will get extensive use. The national academy of sciences is a private, nonprofit, selfperpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the. One of the most timeconsuming activities in research laboratories is looking. How to fill in pdf forms in adobe acrobat or reader. Thank you for using the download pdf file feature, to. This chapter concentrates on the pathology of the more common pathogens of the laboratory rat. So you are absolutely right, thats not expected and it works on all our test computers in the lab for example, so lets try some troubleshooting to find out whats wrong.
With the left mouse button, click the location where you want to insert the copied passage or image. The laboratory mouse mus musculus has long been used as a model organism to test hypotheses and treatments related to understanding the mechanisms of disease in humans. The most common closure patterns are simple interrupted and simple continuous. In preparation for the volumetric analysis experiment, each pair of students must obtain about 3 grams of potassium acid phthalate, khp, in a vial and dry it in the oven at for 2 hours at 110.
Grab the mouse s neck, with fingers touching the shoulder blades. However, information on centrifugation theory and separation techniques are usually only found in centrifuge. Record all new cage information to add to the mouse list in the lab. Standard operating procedure for tamoxifen in animals 1.
Malocclusion in the laboratory mouse research office. One of the most timeconsuming activities in research laboratories is looking up information specific to the species or strain of animal being used. Many pathogens have been reported to cause disease in the laboratory rat. Mouse genetics student guide prelab information purpose explore the relationship between genotype and phenotype. Download this app from microsoft store for windows 10, windows 10 mobile, windows 10 team surface hub, hololens. These steps will show you how to use a pc and mac computer mouse. Arc mouse, sculpt comfort mouse, bluetooth notebook mouse 5000, wireless mouse 2000, wireless mobile mouse, wireless mobile mouse 3000, wireless mobile mouse 3500, wireless mobile mouse 4000, wireless mouse 5000, comfort mouse 3000, comfort mouse 4500, comfort mouse 6000, basic optical mouse 500, compact optical mouse. In the past 25 years, genetically engineered mice gem and rats ger have advanced from novelty status to essential tools in biomedical research programs.
Enzyme linked immunosorbent assay elisa is a very sensitive immunochemical technique which is used to access the presence of specific protein antigen or antibody in the given. Guide for the care and use of laboratory animals 1996 rodents 1996 nutrient requirements of laboratory animals, fourth revised edition 1995 laboratory animal management. Cd1icr strain origin the original group of swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a noninbred stock in the laboratory. A note icon appears to the right of the markup to indicate the. If weaning pups before day 21, place a food gel in the cage.
859 169 1130 847 628 1545 479 409 1472 1291 1000 859 102 1017 600 562 1598 1620 436 115 1516 214 1294 1420 1414 1127 805 1447 1284 600 1499 642 1112 1334 1009 1227 1169 616 790 1096